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DNA damage in Molt-4 T-lymphoblastoid cells exposed to cellular telephone RFs In Vitro
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19.02.2006
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DNA damage in Molt-4 T-lymphoblastoid cells exposed to cellular telephone radiofrequency fields in vitro
Jerry L. Phillips , Oleg Ivaschuk, Tamako Ishida-Jones, Robert A. Jones, Mary Campbell-Beachler, Wendy Haggren
Pettis VA Medical Center, Research 151, Loma Linda, CA 92357, USA
Received 3 November 1997; revised 16 December 1997; accepted 9 January 1998
Abstract
Molt-4 T-lymphoblastoid cells have been exposed to pulsed signals at cellular telephone frequencies of 813.5625 MHz iDENw signal.and 836.55 MHz TDMA signal.. These studies were performed at low SAR averages2.4 and 24 mW gy1 for iDENw and 2.6 and 26 mW gy1 for TDMA. in studies designed to look for athermal RF effects. The alkaline comet, or single cell gel electrophoresis, assay was employed to measure DNA single-strand breaks in cell cultures exposed to the radiofrequency RF. signal as compared to concurrent sham-exposed cultures. Tail moment and comet extent were calculated as indicators of DNA damage. Statistical differences in the distribution of values for tail moment and comet extent between exposed and control cell cultures were evaluated with the Kolmogorov–Smirnoff distribution test. Data points for all experiments of each exposure condition were pooled and analyzed as single groups. It was found that: 1) exposure of cells to the iDENw signal at an SAR of 2.4 mW gy1 for 2 h or 21 h significantly decreased DNA damage;
2) exposure of cells to the TDMA signal at an SAR of 2.6 mW gy1 for 2 h and 21 h significantly decreased DNA damage;
3) exposure of cells to the iDENw signal at an SAR of 24 mW gy1 for 2h and 21 h significantly increased DNA damage; 4. exposure of cells to the TDMA signal at an SAR of 26 mW gy1 for 2 h significantly decreased DNA damage. The data indicate a need to study the effects of exposure to RF signals on direct DNA damage and on the rate at which DNA damage is repaired. q1998 Elsevier Science S.A.
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Hits: 427
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Control Study of Residential and Personal Magnetic Field Measures and Miscarriges
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19.02.2006
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Geraldine M. Lee, Raymond R. Neutra, Lilia Hristova, Michael Yost, and
Robert A. Hiatt
Abstract:
We conducted a nested case-control study (177 cases, 550 controls) to assess the relation between retrospective magnetic field measures and clinical miscarriage among members
of the northern California Kaiser Permanente medical care system. We also conducted a prospective substudy of 219 participants of the same parent cohort to determine whether 12-week and 30-week exposure assessments were similar. We evaluated wire codes, area measures, and three personal meter metrics: (1) the average difference between consecutive levels (a rate-of-change metric), (2) the maximum level, and (3) the time-weighted average. For wire codes and area measures we found little association. For the personal metrics (30 weeks after last menstrual period), we found positive associations. Each exposure was divided into quartiles, with the lowest quartile as referent. Starting with the highest quartile, adjusted odds ratios and 95% confidence intervals were 3.1 (95% CI 1.6–6.0), 2.3 (95% CI 1.2– 4.4), and 1.5 (95% CI
0.8 –3.1) for the rate-of-change metric; 2.3 (95% CI 1.2– 4.4), 1.9 (95% CI 1.0 –3.5), and 1.4 (95% CI 0.7–2.8) for the maximum value; and 1.7 (95% CI 0.9 –3.3), 1.7 (95% CI 0.9 –3.3), and 1.7 (95% CI 0.9 –3.3) for the timeweighted average. The odds ratio conveyed by being above a 24-hour time-weighted average of 2 milligauss was 1.0 (95% CI 0.5–2.1). Exposure assessment measurements at 12 weeks were poorly correlated with those taken at 30 weeks. Nonetheless, the prospective substudy results regarding miscarriage risk were consistent with the nested study results.
(EPIDEMIOLOGY 2002;13:21–31)
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COFAM Study
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19.02.2006
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Effects of global communication system radio-frequency fields on well being and congnitive functions of human subjects with and without subjective complaints.
Prof dr. ir. A.P.M. Zwamborn, Dr. ir. S.H.J.A. Vossen, ir. B.J.A.M. van Leersum, ing. M.A. Ouwens, W.N. Mäkel - september 2003 Abstract
In this report a double blind randomized three-way crossover evaluation of general symptoms and cognitive functions with or without exposure to GSM and UMTS-like fields in subjects presenting with complaints subjectively attributed to GSM fields is presented. From our research it is concluded that our hypotheses to find no relation between presence of RF-fields and the measured parameters is rejected. We have found statistically significant relation between UMTS-like fields with a field strength of 1 V/m and an effect on the Well Being. Further, from the cognitive tasks, it is observed that a number of significant effects is found. Each exposure frequency is associated with changes in some tasks or parameters, while other frequencies are not. In our study, it is shown that the thermal effects are negligible and therefore, an explanation based on thermal effects seems highly unlikely for effects on the cognitive parameters. Without any question, the results justfiy more scientific research into this area.
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Cherry on safe exposure levels
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19.02.2006
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Dr. Neil Cherry - Lincoln University - 25/4/2000 Overview of this report:
Public health protection standards for toxic substances, chemicals, drugs, air pollution, ionizing radiation are set by WHO, IARC, E.U., U.S. EPA and the U.K. Royal Commission on Environmental Pollution primarily using epidemiological evidence and secondarily using animal evidence. WHO and ICNIRP base non-ionizing radiation protection standards on a single biological mechanism, Tissue Heating. They systematically reject or ignore all epidemiological and animal evidence of non-thermal effects, for which there is a large body.
The history and basis of the RF-Thermal View which dominates ICNIRP, WHO, and national authority approaches, is documented and summarized. It will be shown that throughout the post-War period scientific research and leading biological and medical scientists have challenged the RF-thermal assumptions. They present very strong evidence, amounting to proof, that biological systems intrinsically use EMR for body, organ, hormone and cellular functions and regulation, and that extrinsic EMR interferes with these at extremely low exposure levels. These biological effects do not involve heat but do involve non-linear, non-equilibrium resonant interactions between ELF oscillating signals.
The well documented and established nonthermal biological effects of EMR include significant alteration of cellular calcium ion homeostasis, reduction of melatonin and the detection of Schumann Resonances by human and avian brains, DNA strand breakage and enhanced chromosome aberrations.
The human health implications of these biological effects are discussed and documented. This shows that calcium ion efflux/influx and melatonin reduction are separately and jointly linked to DNA strand breaks, chromosome aberrations, enhanced proto oncogene activity, impaired immune system competence and impaired neurological and cardiac functioning. Many projects, from independent labotories, have observed and reported that all of these effects are significantly related to EMR exposure.
Human Biometeorology is a whole body of research that is ignored by ICNIRP. This has provided the proof over 30 years ago that human brains detect and use the Schumann Resonances for synchronization of biological rhythms, i.e. as a Zeitgeber. This observation on its own is an absolute challenge to the validity of the ICNIRP assumptions that there are no established non-thermal biological effects.
Epidemiological reviews by Dr John Goldsmith show that adverse health effects, such as neurological, reproductive and cancer effects have been observed in EMR exposed populations. Based on this, and the traditional public health protection approach, Dr Goldsmith challenges the validity of the ICNIRP guideline and approach.
To summarize the scientific evidence an initial set of eight bioelectromagnetic principles are proposed and a brief summary of the scientific research that supports them is given. They are:
EMR is intrinsic to our bodies.
Our brains are the most electrically sensitive organs in our bodies.
Our hearts are electrically sensitive.
Cells are sensitive to EMR.
Our whole body acts as an aerial.
The brain is linked to organs and cells through EMR-sensitive hormones.
The EMR Spectrum Principle.
The Intrinsic Free Radical Principle.
These principles provide a sound and scientifically reliable approach to assessing EMR impacts on people and animals. They soundly challenge the ICNIRP assumptions and approach. The ICNIRP assessment of biological mechanisms is reviewed and found to be selective, limited and flawed. Their assessment of RF/MW effects on reproductive outcomes is shown to be limited, misleading and flawed. The cancer assessment is shown to be selective, misleading, inappropriate and flawed. An incorrect epidemiological approach is consistently applied.
From the data in the studies cited (and misused) by the ICNIRP and WHO reviews, and supported by a great deal of other available research evidence, a public health protection standard is recommended based on residential dose-response relationships for cancer, neurological effects and reproductive effects.
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Hits: 437
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Cell phone radiation poses a serious biological and health risk
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19.02.2006
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Dr. Neil Cherry - May 2001
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